The Association Between Insulin Use and Asthma: An Epidemiological Observational Analysis and Mendelian Randomization Study

孟德尔随机化 哮喘 医学 队列 胰岛素 糖尿病 流行病学 队列研究 全国健康与营养检查调查 人口 内科学 环境卫生 内分泌学 生物 生物化学 遗传变异 基因 基因型
作者
Zikai Lin,Junfeng Huang,Shuojia Xie,Ziwen Zheng,Kailun Tang,Shiyue Li,Ruchong Chen
出处
期刊:Lung [Springer Science+Business Media]
卷期号:201 (2): 189-199 被引量:4
标识
DOI:10.1007/s00408-023-00611-z
摘要

Asthma is a common respiratory disease caused by genetic and environmental factors, but the contribution of insulin use to the risk of asthma remains unclear. This study aimed to investigate the association between insulin use and asthma in a large population-based cohort, and further explore their causal relationship by Mendelian randomization (MR) analysis. An epidemiological study including 85,887 participants from the National Health and Nutrition Examination Survey (NHANES) 2001–2018 was performed to evaluate the association between insulin use and asthma. Based on the inverse-variance weighted approach, MR analysis were conducted to estimate the causal effect of insulin use on asthma from the UKB and FinnGen datasets, respectively. In the NHANES cohort, we found that insulin use was associated with an increased risk of asthma [odd ratio (OR) 1.38; 95% CI 1.16–1.64; p < 0.001]. For the MR analysis, we found a causal relationship between insulin use and a higher risk of asthma in both Finn (OR 1.10; p < 0.001) and UK Biobank cohorts (OR 1.18; p < 0.001). Meanwhile, there was no causal association between diabetes and asthma. After multivariable adjustment for diabetes in UKB cohort, the insulin use remained significantly associated with an increased risk of asthma (OR 1.17, p < 0.001). An association between insulin use and an increased risk of asthma was found via the real-world data from the NHANES. In addition, the current study identified a causal effect and provided a genetic evidence of insulin use and asthma. More studies are needed to elucidate the mechanisms underlying the association between insulin use and asthma.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
上官若男应助xyz采纳,获得10
1秒前
风起枫落完成签到,获得积分10
1秒前
1秒前
1秒前
夕颜完成签到,获得积分10
2秒前
李健的小迷弟应助魏少爷采纳,获得10
2秒前
羊羊杨发布了新的文献求助10
2秒前
啊啊发布了新的文献求助10
2秒前
2秒前
Ppp发布了新的文献求助10
2秒前
zd发布了新的文献求助10
2秒前
陈念完成签到,获得积分10
3秒前
4秒前
哈哈王发布了新的文献求助10
6秒前
6秒前
6秒前
7秒前
8秒前
自由的半蕾完成签到,获得积分10
8秒前
pp63应助科研通管家采纳,获得100
9秒前
大模型应助科研通管家采纳,获得10
9秒前
9秒前
传奇3应助科研通管家采纳,获得10
9秒前
科研通AI2S应助科研通管家采纳,获得10
9秒前
情怀应助科研通管家采纳,获得10
9秒前
YamDaamCaa应助科研通管家采纳,获得30
9秒前
慕青应助科研通管家采纳,获得10
9秒前
YamDaamCaa应助科研通管家采纳,获得30
9秒前
9秒前
sisyphus_yy发布了新的文献求助10
9秒前
10秒前
挺萌的小龙虾完成签到,获得积分10
11秒前
一个爱吃爱睡的团子完成签到,获得积分10
11秒前
活力书包完成签到 ,获得积分10
11秒前
11秒前
undeaddl1发布了新的文献求助10
11秒前
科研通AI2S应助斗牛的番茄采纳,获得10
12秒前
菰蒲完成签到,获得积分10
12秒前
迟迟发布了新的文献求助20
12秒前
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975755
求助须知:如何正确求助?哪些是违规求助? 3520108
关于积分的说明 11200829
捐赠科研通 3256492
什么是DOI,文献DOI怎么找? 1798298
邀请新用户注册赠送积分活动 877509
科研通“疑难数据库(出版商)”最低求助积分说明 806403