The Association Between Insulin Use and Asthma: An Epidemiological Observational Analysis and Mendelian Randomization Study

孟德尔随机化 哮喘 医学 队列 胰岛素 糖尿病 流行病学 队列研究 全国健康与营养检查调查 人口 内科学 环境卫生 内分泌学 生物 生物化学 遗传变异 基因 基因型
作者
Zikai Lin,Junfeng Huang,Shuojia Xie,Ziwen Zheng,Kailun Tang,Shiyue Li,Ruchong Chen
出处
期刊:Lung [Springer Science+Business Media]
卷期号:201 (2): 189-199 被引量:4
标识
DOI:10.1007/s00408-023-00611-z
摘要

Asthma is a common respiratory disease caused by genetic and environmental factors, but the contribution of insulin use to the risk of asthma remains unclear. This study aimed to investigate the association between insulin use and asthma in a large population-based cohort, and further explore their causal relationship by Mendelian randomization (MR) analysis. An epidemiological study including 85,887 participants from the National Health and Nutrition Examination Survey (NHANES) 2001–2018 was performed to evaluate the association between insulin use and asthma. Based on the inverse-variance weighted approach, MR analysis were conducted to estimate the causal effect of insulin use on asthma from the UKB and FinnGen datasets, respectively. In the NHANES cohort, we found that insulin use was associated with an increased risk of asthma [odd ratio (OR) 1.38; 95% CI 1.16–1.64; p < 0.001]. For the MR analysis, we found a causal relationship between insulin use and a higher risk of asthma in both Finn (OR 1.10; p < 0.001) and UK Biobank cohorts (OR 1.18; p < 0.001). Meanwhile, there was no causal association between diabetes and asthma. After multivariable adjustment for diabetes in UKB cohort, the insulin use remained significantly associated with an increased risk of asthma (OR 1.17, p < 0.001). An association between insulin use and an increased risk of asthma was found via the real-world data from the NHANES. In addition, the current study identified a causal effect and provided a genetic evidence of insulin use and asthma. More studies are needed to elucidate the mechanisms underlying the association between insulin use and asthma.
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