332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice

Serotonergic psychedelics are gaining increasing interest as potential therapeutics for a range of mental illnesses. Compounds with short-lived subjective effects may be clinically useful because dosing time would be reduced, improving patient access. The short-acting psychedelic is 5-MeO-DMT has been associated with improvement in depression and anxiety symptoms in early clinical studies. However relatively little is known about the behavioral effects and neural mechanisms of 5-MeO-DMT in mice.