Preferential modulation of individual retinal ganglion cells by electrical stimulation

刺激 神经科学 视网膜 视网膜 视网膜植入物 视觉假肢 细胞外 光刺激 生物
作者
Molis Yunzab,Artemio Soto-Breceda,Matias Maturana,Stephanie Kirkby,Maximilian Slattery,Anton Newgreen,Hamish Meffin,Tatiana Kameneva,Anthony N Burkitt,Michael Ibbotson,Wei Tong
出处
期刊:Journal of Neural Engineering [IOP Publishing]
卷期号:19 (4): 045003-045003
标识
DOI:10.1088/1741-2552/ac861f
摘要

Objective.Retinal prostheses have had limited success in vision restoration through electrical stimulation of surviving retinal ganglion cells (RGCs) in the degenerated retina. This is partly due to non-preferential stimulation of all RGCs near a single stimulating electrode, which include cells that conflict in their response properties and their contribution to visiual processing. Our study proposes a stimulation strategy to preferentially stimulate individual RGCs based on their temporal electrical receptive fields (tERFs).Approach.We recorded the responses of RGCs using whole-cell patch clamping and demonstrated the stimulation strategy, first using intracellular stimulation, then via extracellular stimulation.Main results. We successfully reconstructed the tERFs according to the RGC response to Gaussian white noise current stimulation. The characteristics of the tERFs were extracted and compared based on the morphological and light response types of the cells. By re-delivering stimulation trains that were composed of the tERFs obtained from different cells, we could preferentially stimulate individual RGCs as the cells showed lower activation thresholds to their own tERFs.Significance.This proposed stimulation strategy implemented in the next generation of recording and stimulating retinal prostheses may improve the quality of artificial vision.
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