Preferential modulation of individual retinal ganglion cells by electrical stimulation

刺激 神经科学 视网膜 视网膜 视网膜植入物 视觉假肢 细胞外 光刺激 生物
作者
Molis Yunzab,Artemio Soto-Breceda,Matias Maturana,Stephanie Kirkby,Maximilian Slattery,Anton Newgreen,Hamish Meffin,Tatiana Kameneva,Anthony N Burkitt,Michael Ibbotson,Wei Tong
出处
期刊:Journal of Neural Engineering [IOP Publishing]
卷期号:19 (4): 045003-045003
标识
DOI:10.1088/1741-2552/ac861f
摘要

Objective.Retinal prostheses have had limited success in vision restoration through electrical stimulation of surviving retinal ganglion cells (RGCs) in the degenerated retina. This is partly due to non-preferential stimulation of all RGCs near a single stimulating electrode, which include cells that conflict in their response properties and their contribution to visiual processing. Our study proposes a stimulation strategy to preferentially stimulate individual RGCs based on their temporal electrical receptive fields (tERFs).Approach.We recorded the responses of RGCs using whole-cell patch clamping and demonstrated the stimulation strategy, first using intracellular stimulation, then via extracellular stimulation.Main results. We successfully reconstructed the tERFs according to the RGC response to Gaussian white noise current stimulation. The characteristics of the tERFs were extracted and compared based on the morphological and light response types of the cells. By re-delivering stimulation trains that were composed of the tERFs obtained from different cells, we could preferentially stimulate individual RGCs as the cells showed lower activation thresholds to their own tERFs.Significance.This proposed stimulation strategy implemented in the next generation of recording and stimulating retinal prostheses may improve the quality of artificial vision.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
澤少发布了新的文献求助10
1秒前
小马甲应助快乐科研采纳,获得10
2秒前
2秒前
2秒前
要减肥山槐完成签到,获得积分10
2秒前
jane完成签到 ,获得积分10
2秒前
李健鹏完成签到 ,获得积分10
2秒前
2秒前
afli完成签到 ,获得积分0
2秒前
cadnash发布了新的文献求助10
3秒前
王锋发布了新的文献求助10
3秒前
Maroon5完成签到,获得积分10
3秒前
4秒前
医学小生完成签到 ,获得积分10
4秒前
5秒前
欢欢发布了新的文献求助10
5秒前
6秒前
6秒前
满意凡桃发布了新的文献求助10
7秒前
桂花酒酿完成签到,获得积分10
7秒前
7秒前
自由的聋五完成签到,获得积分20
8秒前
8秒前
8秒前
Lucas应助苏黎世采纳,获得10
9秒前
科研通AI2S应助Licy采纳,获得10
9秒前
简单以冬发布了新的文献求助10
9秒前
10秒前
Leohp发布了新的文献求助10
10秒前
荀中道发布了新的文献求助10
10秒前
哈哈哈大赞完成签到,获得积分10
10秒前
澤少完成签到,获得积分10
10秒前
chen666完成签到,获得积分10
10秒前
11秒前
王锋完成签到,获得积分10
11秒前
晨Zhi完成签到,获得积分10
12秒前
13秒前
13秒前
cangye完成签到,获得积分10
14秒前
快乐的晟睿完成签到,获得积分10
14秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970172
求助须知:如何正确求助?哪些是违规求助? 3514982
关于积分的说明 11176568
捐赠科研通 3250212
什么是DOI,文献DOI怎么找? 1795198
邀请新用户注册赠送积分活动 875702
科研通“疑难数据库(出版商)”最低求助积分说明 805004