Conjugate Addition of Acetal-Derived Benzyl Radicals Generated from Low-Valent Titanium-Mediated C–O Bond Cleavage

Abstract A new method for the generation of benzyl radicals from acetals via low-valent titanium-mediated homolytic C–O bond cleavage is presented. The low cost and availability of the developed titanium reagent enable efficient access to α-alkoxy carbon radical species via the developed reaction.