Ion channels and hypoxia pulmonary vasoconstriction

Oxygen-sensitive ion channels widely expresses in pulmonary vascular smooth muscle cells,which determine vascular tone in hypoxia and are involved in hypoxia pulmonary vasoconstriction. The paper summarizes that roles of K+ and Ca2+ channels in acute and chronic hypoxia pulmonary vasoconstriction. Key words: Hypoxia pulmonary vasoconstriction;  K+ channels;  Ca2+ channels;  Hypoxia pulmonary hypertension