化学
立体选择性
废止
磷化氢
串联
产量(工程)
催化作用
吡咯
组合化学
选择性
反应条件
级联反应
药物化学
有机化学
冶金
材料科学
复合材料
作者
Zonghao Dai,Jin Zhu,Wenbo Su,Wuxian Zeng,Ziqi Liu,Ming Chen,Qingfa Zhou
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-08-20
卷期号:22 (17): 7008-7012
被引量:32
标识
DOI:10.1021/acs.orglett.0c02558
摘要
A phosphine-catalyzed tandem cyclization reaction has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives, which contain three consecutive asymmetric centers. The reaction has a good yield, excellent stereoselectivity, and Z/E selectivity. The new method is simple, requires only mild conditions, and shows tolerance for various functional groups. Similarly, this reaction can be catalyzed by a chiral phosphine catalyst to achieve asymmetric synthesis.
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