尿素酶
化学
对接(动物)
体外
酶
抑制性突触后电位
组合化学
立体化学
生物化学
医学
生物
护理部
神经科学
作者
Hummera Rafique,Fizza Tahira,Syeda Zar Afshan,Muhammad Naseem,Naghmana Kausar,Aamer Saeed,Muhammad Sharif
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2020-03-25
卷期号:17 (4): 254-259
被引量:3
标识
DOI:10.2174/1570178616666191004111058
摘要
Synthesis of some 1,1'-diaryl-3,3'-(p-phenylenedicarbonyl)dithioureas was accomplished in two steps. Dithioureas were prepared under inert conditions with significantly high yields. Inhibitory activity of dithiourea compounds was investigated against urease enzyme. All the synthesized compounds were evaluated for their urease inhibitory activities, and molecular docking studies were carried out to ascertain the inhibitor binding mode with the enzyme. All the compounds displayed moderate to significant urease inhibitory activities.
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