Hyperspectral Imaging (HSI) of Human Kidney Allografts

医学 灌注 机器灌注 肾移植 高光谱成像 缺血 移植 泌尿科 吻合 薄壁组织 核医学 病理 外科 放射科 心脏病学 内科学 肝移植 地质学 遥感
作者
Robert Sucher,Tristan Wagner,Helmut Köhler,Elisabeth Sucher,Hanna Guice,Sebastian Recknagel,Andri Lederer,Hans Michael Hau,Sebastian Rademacher,Stefan Schneeberger,Gerald Brandacher,Ines Gockel,Daniel Seehofer
出处
期刊:Annals of Surgery [Ovid Technologies (Wolters Kluwer)]
卷期号:276 (1): e48-e55 被引量:22
标识
DOI:10.1097/sla.0000000000004429
摘要

Objective: Aim of our study was to test a noninvasive HSI technique as an intraoperative real time assessment tool for deceased donor kidney quality and function in human kidney allotransplantation. Summary of Background Data: HSI is capable to deliver quantitative diagnostic information about tissue pathology, morphology, and composition, based on the spectral characteristics of the investigated tissue. Because tools for objective intraoperative graft viability and performance assessment are lacking, we applied this novel technique to human kidney transplantation. Methods: Hyperspectral images of distinct components of kidney allografts (parenchyma, ureter) were acquired 15 and 45 minutes after reperfusion and subsequently analyzed using specialized HSI acquisition software capable to compute oxygen saturation levels (StO 2 ), near infrared perfusion indices (NIR), organ hemoglobin indices, and tissue water indices of explored tissues. Results: Seventeen kidney transplants were analyzed. Median recipient and donor age were 55 years. Cold ischemia time was 10.8 ± 4.1 hours and anastomosis time was 35 ± 7 minutes (mean ± standard deviation). Two patients (11.8%) developed delayed graft function (DGF). cold ischemia time was significantly longer (18.6 ± 1.6) in patients with DGF (P < 0.01). Kidneys with DGF furthermore displayed significant lower StO 2 (P = 0.02) and NIR perfusion indices, 15 minutes after reperfusion (P < 0.01). Transplant ureters displayed a significant decrease of NIR perfusion with increased distance to the renal pelvis, identifying well and poor perfused segments. Conclusion: Intraoperative HSI is feasible and meaningful to predict DGF in renal allografts. Furthermore, it can be utilized for image guided surgery, providing information about tissue oxygenation, perfusion, hemoglobin concentration, and water concentration, hence allowing intraoperative viability assessment of the kidney parenchyma and the ureter.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
今后应助xlp采纳,获得10
1秒前
神勇的雅香完成签到,获得积分0
1秒前
学术通zzz完成签到,获得积分0
1秒前
1秒前
1秒前
1秒前
1秒前
情怀应助顺利的愫采纳,获得10
1秒前
爱撒娇的长颈鹿完成签到,获得积分10
2秒前
杨天水发布了新的文献求助10
2秒前
星辰大海应助清爽大山采纳,获得10
2秒前
unfair完成签到,获得积分10
2秒前
3秒前
4秒前
完美世界应助Vivi采纳,获得10
4秒前
科研通AI5应助MFiWanting采纳,获得10
4秒前
4秒前
听话的寄灵完成签到,获得积分10
5秒前
Albert发布了新的文献求助30
6秒前
旦斯特尼发布了新的文献求助10
6秒前
zhang005on发布了新的文献求助10
6秒前
GGB完成签到,获得积分20
7秒前
7秒前
科研通AI5应助zoey采纳,获得10
7秒前
彭于晏应助余书文采纳,获得10
7秒前
科研通AI2S应助秀丽的初柔采纳,获得10
8秒前
轩贝完成签到,获得积分10
8秒前
寻度完成签到,获得积分10
8秒前
8秒前
8秒前
shiqiyu发布了新的文献求助10
9秒前
望月完成签到,获得积分10
10秒前
10秒前
GGB发布了新的文献求助10
10秒前
ANDRT发布了新的文献求助10
11秒前
0318完成签到,获得积分10
11秒前
LLLHHH完成签到,获得积分10
11秒前
12秒前
隐形曼青应助小草采纳,获得10
12秒前
鹿飞完成签到,获得积分10
12秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546979
求助须知:如何正确求助?哪些是违规求助? 3123961
关于积分的说明 9357531
捐赠科研通 2822555
什么是DOI,文献DOI怎么找? 1551574
邀请新用户注册赠送积分活动 723561
科研通“疑难数据库(出版商)”最低求助积分说明 713801