生物
病毒学
免疫病理学
病毒
单反病毒
免疫系统
肺病毒科
免疫学
副粘病毒科
病毒性疾病
乙型肝炎病毒
正庚病毒
接种疫苗
肺病毒
丙型肝炎病毒
白细胞介素10
七鳃鳗科
作者
Jie Yang,Chen Ma,Yu Zhao,Anjing Fan,Xiufen Zou,Zishu Pan
摘要
In the past few decades, respiratory syncytial virus (RSV) has still been a major health concern worldwide. The vaccine-enhance disease (VED) has hindered RSV vaccine development. A truncated hepatitis B virus core protein vaccine containing the conserved region (amino acids 144 to 204) of the RSV G protein (HBc-tG) had previously been shown to induce effective immune responses and confer protection against RSV infection in mice but to also lead to VED. In this study, we investigated the effect of IL-35 on the host response and immunopathology following RSV infection in vaccinated mice. Our results indicate that HBc-tG together with IL-35 elicited a balanced immune response and protected mice against RSV infection without vaccine-enhanced immunopathology. Applying a systems biology method, we identified Il10 to be the key regulator in reducing the excessive lung inflammation. Our study provides new insight into the function of IL-35 and its regulatory mechanism of VED at the network level.
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