亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Associations between depression, lifestyle and brain structure: A longitudinal MRI study

萧条(经济学) 眶额皮质 灰质 内科学 心理学 纵向研究 医学 体质指数 心脏病学 精神科 磁共振成像 认知 病理 前额叶皮质 白质 经济 宏观经济学 放射科
作者
Julia Binnewies,Laura Nawijn,Marie‐José van Tol,Nic J.A. van der Wee,Dick J. Veltman,Brenda W.J.H. Penninx
出处
期刊:NeuroImage [Elsevier BV]
卷期号:231: 117834-117834 被引量:43
标识
DOI:10.1016/j.neuroimage.2021.117834
摘要

Depression has been associated with decreased regional grey matter volume, which might partly be explained by an unhealthier lifestyle in depressed individuals which has been ignored by most earlier studies. Also, the longitudinal nature of depression, lifestyle and brain structure associations is largely unknown. This study investigates the relationship of depression and lifestyle with brain structure cross-sectionally and longitudinally over up to 9 years. We used longitudinal structural MRI data of persons with depression and/or anxiety disorders and controls (Nunique participants = 347, Nobservations = 609). Cortical thickness of medial orbitofrontal cortex (mOFC), rostral anterior cingulate cortex (rACC) and hippocampal volume were derived using FreeSurfer. Using Generalized Estimating Equations, we investigated associations of depression and lifestyle (Body mass index (BMI), smoking, alcohol consumption, physical activity and sleep duration) with brain structure and change in brain structure over 2 (n = 179) and 9 years (n = 82). Depression status (B = -.053, p = .002) and severity (B = -.002, p = .002) were negatively associated with rACC thickness. mOFC thickness was negatively associated with BMI (B = -.004, p < .001) and positively with moderate alcohol consumption (B = .030, p = .009). All associations were independent of each other. No associations were observed between (change in) depression, disease burden or lifestyle factors with brain change over time. Depressive symptoms and diagnosis were independently associated with thinner rACC, BMI with thinner mOFC, and moderate alcohol consumption with thicker mOFC. No longitudinal associations were observed, suggesting that regional grey matter alterations are a long-term consequence or vulnerability indicator for depression but not dynamically or progressively related to depression course trajectory.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
10秒前
璐璐侠完成签到,获得积分10
15秒前
1分钟前
AJ完成签到 ,获得积分10
1分钟前
xiaozou55完成签到 ,获得积分10
1分钟前
binyao2024完成签到,获得积分10
2分钟前
光亮静槐完成签到 ,获得积分10
2分钟前
lrl350495627发布了新的文献求助10
3分钟前
lrl350495627完成签到,获得积分10
3分钟前
GingerF应助科研通管家采纳,获得50
4分钟前
FashionBoy应助andrele采纳,获得10
4分钟前
4分钟前
自然芷文发布了新的文献求助10
5分钟前
5分钟前
我是老大应助自然芷文采纳,获得10
5分钟前
iNk应助吗喽采纳,获得20
5分钟前
研友_VZG7GZ应助科研通管家采纳,获得10
6分钟前
打打应助科研通管家采纳,获得10
6分钟前
Charlie完成签到 ,获得积分10
6分钟前
CodeCraft应助Benhnhk21采纳,获得30
6分钟前
6分钟前
Benhnhk21发布了新的文献求助30
7分钟前
科研通AI2S应助科研通管家采纳,获得10
7分钟前
村口的帅老头完成签到 ,获得积分0
8分钟前
8分钟前
gincle完成签到 ,获得积分10
8分钟前
8分钟前
andrele发布了新的文献求助10
8分钟前
8分钟前
9分钟前
积极的台灯完成签到,获得积分10
9分钟前
紫荆完成签到,获得积分10
9分钟前
Johnson完成签到 ,获得积分10
9分钟前
李健应助科研通管家采纳,获得10
10分钟前
Benhnhk21发布了新的文献求助10
10分钟前
wanci应助淡然绝山采纳,获得10
10分钟前
10分钟前
wkjfh应助YaoQi采纳,获得10
11分钟前
dyuguo3完成签到 ,获得积分10
11分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990181
求助须知:如何正确求助?哪些是违规求助? 3532136
关于积分的说明 11256472
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805190
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234