自噬
福克斯O1
甘丙肽
细胞生物学
程序性细胞死亡
生物
细胞凋亡
线粒体
信号转导
神经肽
生物化学
受体
蛋白激酶B
作者
Ilenia Martinelli,Andréi Timotin,Paula Moreno-Corchado,Dimitri Marsal,Solomiia Kramar,Halina Loy,Carine Joffre,Frédéric Boal,Hélène Tronchère,Oksana Kunduzova
出处
期刊:Redox biology
[Elsevier]
日期:2021-04-01
卷期号:40: 101866-101866
被引量:20
标识
DOI:10.1016/j.redox.2021.101866
摘要
Autophagy and apoptosis are powerful regulators of multiple facets of cellular metabolism and homeostasis. Here, we uncover that galanin, a pleiotropic peptide, regulates cardiac autophagy and deactivates apoptotic cell death through the Forkhead box protein O1 (FoxO1) pathway. In hypertrophied heart, galanin promotes autophagy and metabolic shift from fatty acid (FA) to glucose oxidation and preserves mitochondrial integrity. In cardiomyoblasts, galanin triggers autophagosome formation and alleviates hypertrophy, apoptotic cell death, and mitochondrial stress. Mechanistically, galanin dictates cell autophagic and anti-apoptotic phenotypes through FoxO1 pathway. Together, these findings uncover a previously unknown role for galanin in the regulation of cardiac autophagy and provide new insights into the molecular mechanisms supporting cell survival in the hypertrophic reprogramming of the heart.
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