舌头
肌萎缩侧索硬化
电阻抗肌描记术
电极
生物医学工程
电阻抗
医学
化学
病理
物理
疾病
内科学
量子力学
血管舒张
物理化学
作者
Chlöe N. Schooling,T. Jamie Healey,Harry E. McDonough,Sophie J. French,Christopher McDermott,Pamela J. Shaw,Visakan Kadirkamanathan,James J. P. Alix
出处
期刊:Physiological Measurement
[IOP Publishing]
日期:2020-11-18
卷期号:41 (12): 125008-125008
被引量:6
标识
DOI:10.1088/1361-6579/abcb9b
摘要
Abstract Objective : Electrical impedance myography (EIM) performed on the centre of the tongue shows promise in detecting amyotrophic lateral sclerosis (ALS). Lateral recordings may improve diagnostic performance and provide pathophysiological insights through the assessment of asymmetry. However, it is not known if electrode proximity to the muscle edge, or electrode rotation, distort spectra. We evaluated this using finite element-based modelling. Approach : Nine thousand EIM from patients and healthy volunteers were used to develop a finite element model for phase and magnitude. Simulations varied electrode proximity to the muscle edge and electrode rotation. LT-Spice simulations assessed disease effects. Patient data were assessed for reliability, agreement and classification performance. Main results : No effect on phase spectra was seen if all electrodes remained in contact with the tissue. Small effects on magnitude were observed. Cole-Cole circuit simulations indicated capacitance reduced with disease severity. Lateral tongue muscle recordings in both patients and healthy volunteers were reproducible and symmetrical. Combined lateral/central tongue EIM improved disease classification compared to either placement alone. Significance : Lateral EIM tongue measurements using phase angle are feasible. Such measurements are reliable, find no evidence of tongue muscle asymmetry in ALS and improve disease classification. Lateral measurements enhance tongue EIM in ALS.
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