ChemInform Abstract: Synthesis and Muscarinic Activity of a Series of Tertiary and Quaternary N-Substituted Guvacine Esters Structurally Related to Arecoline and Arecaidine Propargyl Ester.

Abstract Arecoline (I) is N‐demethylated by consecutive treatment with phosgene and hot water to give guvacoline which is isolated as its hydrobromide (II).