辅酶A
还原酶
化学
微粒体
胆固醇
新陈代谢
生物化学
HMG-CoA还原酶
内分泌学
酶
内科学
生物
医学
作者
Ángel Cedazo‐Mínguez,Lars Bäckman,Kurt Einarsson,Ljusk Siw Eriksson,S Ewerth
标识
DOI:10.1016/s0022-2275(20)38111-6
摘要
Obesity is often associated with an elevated total body cholesterol synthesis.In order to evaluate the role of hepatic cholesterogenesis in this phenomenon, we assayed the rate-limiting step in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase in the microsomal fraction of liver biopsies obtained operatively from ten morbidly obese (relative body weight > 155%) subjects.Eighteen normalweight patients (relative body weight < 120%) with cholesterol gallstones served as controls.Hepatic HMG CoA reductase activity, expressed as pmolmin-'mg protein-', was 60% higher in the obese subjects compared to the gallstone patients (P < 0.05).Microsomal protein concentration was lower in the obese patients, so that enzyme activity calculated per gram liver was not significantly different between the two groups.However, mevalonate formation, expressed in terms of total organ activity, was higher in the obese than in the nonobese gr0up.lThe results suggest that the liver is a major contributor to the increased cholesterol production seen in obesity.-Angelin,B., ' L. Backman and S. Ewerth.
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