介孔二氧化硅
前药
癌细胞
阿霉素
材料科学
内吞作用
纳米技术
磁性纳米粒子
药物输送
纳米医学
体内
癌症
生物物理学
癌症研究
纳米颗粒
化学
介孔材料
化疗
生物化学
细胞
医学
生物
催化作用
内科学
生物技术
作者
Weihai Chen,Guo-Feng Luo,Qi Lei,Fengyi Cao,Jin-Xuan Fan,Wen-Xiu Qiu,Hui-Zhen Jia,Sheng Hong,Fang Fang,Xuan Zeng,Ren-Xi Zhuo,Xian-Zheng Zhang
出处
期刊:Biomaterials
[Elsevier]
日期:2016-01-01
卷期号:76: 87-101
被引量:113
标识
DOI:10.1016/j.biomaterials.2015.10.053
摘要
In this paper, a multifunctional theranostic magnetic mesoporous silica nanoparticle (MMSN) with magnetic core was developed for magnetic-enhanced tumor-targeted MR imaging and precise therapy. The gatekeeper β-cyclodextrin (β-CD) was immobilized on the surface of mesoporous silica shell via platinum(IV) prodrug linking for reduction-triggered intracellular drug release. Then Arg-Gly-Asp (RGD) peptide ligand was further introduced onto the gatekeeper β-CD via host-guest interaction for cancer targeting purpose. After active-targeting endocytosis by cancer cells, platinum(IV) prodrug in MMSNs would be restored to active platinum(II) drug in response to the innative reducing microenvironment in cancer cells, resulting in the detachment of β-CD gatekeeper and thus simultaneously triggering the in situ release of anticancer drug doxorubicin (DOX) entrapped in the MMSNs to kill cancer cells. It was found that with the aid of an external magnetic field, drug loaded MMSNs showed high contrast in MR imaging in vivo and exhibited magnetically enhanced accumulation in the cancer site, leading to significant inhibition of cancer growth with minimal side effects. This multifunctional MMSN will find great potential as a theranostic nanoplatform for cancer treatment.
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