氧化应激
丙二醛
斑马鱼
超氧化物歧化酶
化学
溴化物
活性氧
离子液体
DNA损伤
氧化磷酸化
氧化损伤
过氧化氢酶
生物化学
核化学
药物化学
DNA
分子生物学
有机化学
生物
基因
催化作用
作者
Miao Dong,Tong Liu,Jinhua Wang,Jun Wang,Lusheng Zhu,Jun Zhang
摘要
ABSTRACT The present study investigated the toxic effects of 1‐butyl‐3‐methylimidazolium bromide ([C 4 mim]Br) in zebrafish livers after exposure to 5–40 mg/L of [C 4 mim]Br on days 7, 14, 21, and 28. The results showed that low levels of [C 4 mim]Br exposure activated the superoxide dismutase (SOD) activity during early periods of exposure. However, high concentrations (20–40 mg/L) of [C 4 mim]Br caused the inhibition of SOD, which, accordingly , led to excess reactive oxygen species and malondialdehyde. The present results indicate that [C 4 mim]Br causes oxidative stress in the livers of both male and female zebrafish. Additionally, the DNA damage revealed that [C 4 mim]Br has a genotoxic effect on zebrafish livers, even when the concentration of [C 4 mim]Br is low (5 mg/L). The DNA damage was demonstrated by quantifying the DNA strand breakage.
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