Diagnosis and management of coronary artery disease

Coronary artery disease (CAD) is a major cause of morbidity and mortality in the United States. This review considers the diagnosis and therapy of CAD in the general population free of renal disease. Diagnostic methods include clinical examination, noninvasive techniques and catheterization. Pharmacological therapy includes aspirin, beta-blockers, nitrates, calcium antagonists, lipid-lowering agents, and angiotensin-converting enzyme inhibitors. Revascularization includes percutaneous coronary angioplasty and coronary artery bypass grafting. Recent clinical trials that provide the basis for current cardiology guidelines are highlighted, however individualized care is underscored.