Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid

Objective: To clarify the histologic alterations produced by the application of salicylic acid solution, which has been used effectively in chemical peeling without producing a wound or inflammation.Design: We applied 7.5%, 15.0%, and 30.0%salicylic acid in solutions of ethanol or macrogol to the backs of hairless mice for 20 minutes.The skin was histologically evaluated immediately and at 1, 3, 12, 24, and 48 hours following treatment.