The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations

神经科学 心理学 精神分裂症(面向对象编程) 海马结构 功能磁共振成像 白质 丘脑 前额叶皮质 精神病 磁共振弥散成像 听力学 磁共振成像 认知 医学 精神科 放射科
作者
Ali Amad,Arnaud Cachia,Philip Gorwood,Delphine Pins,Christine Delmaire,Benjamin Rolland,Marine Mondino,Pierre Thomas,Renaud Jardri
出处
期刊:Molecular Psychiatry [Springer Nature]
卷期号:19 (2): 184-191 被引量:114
标识
DOI:10.1038/mp.2012.181
摘要

Hallucinations constitute one of the most representative and disabling symptoms of schizophrenia. Several Magnetic Resonance Imaging (MRI) findings support the hypothesis that distinct patterns of connectivity, particularly within networks involving the hippocampal complex (HC), could be associated with different hallucinatory modalities. The aim of this study was to investigate HC connectivity as a function of the hallucinatory modality, that is, auditory or visual. Two carefully selected subgroups of schizophrenia patients with only auditory hallucinations (AH) or with audio-visual hallucinations (A+VH) were compared using the following three complementary multimodal MRI methods: resting state functional MRI, diffusion MRI and structural MRI were used to analyze seed-based Functional Connectivity (sb-FC), Tract-Based Spatial Statistics (TBSS) and shape analysis, respectively. Sb-FC was significantly higher between the HC, the medial prefrontal cortex (mPFC) and the caudate nuclei in A+VH patients compared with the AH group. Conversely, AH patients exhibited a higher sb-FC between the HC and the thalamus in comparison with the A+VH group. In the A+VH group, TBSS showed specific higher white matter connectivity in the pathways connecting the HC with visual areas, such as the forceps major and the inferior-fronto-occipital fasciculus than in the AH group. Finally, shape analysis showed localized hippocampal hypertrophy in the A+VH group. Functional results support the fronto-limbic dysconnectivity hypothesis of schizophrenia, while specific structural findings indicate that plastic changes are associated with hallucinations. Together, these results suggest that there are distinct connectivity patterns in patients with schizophrenia that depend on the sensory-modality, with specific involvement of the HC in visual hallucinations.
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