苄胺
产量(工程)
吡啶
化学
环戊酮
组合化学
药物化学
有机化学
材料科学
催化作用
冶金
作者
Jin Zhou,Hai Li Gao,Han Zhou Sun,Yu Xiong Wu
出处
期刊:Advanced Materials Research
日期:2013-01-01
卷期号:634-638: 1211-1214
被引量:1
标识
DOI:10.4028/www.scientific.net/amr.634-638.1211
摘要
A new practical and efficient route was developed for the synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine, which is a key intermediate of cefpirome. Leading to the formation of the corresponding product, nucleophilic addition, acetylization, Vilsmeier cyclization reaction and dechlorination were employed under mild reaction conditions by using commercially available cyclopentanone and benzylamine as raw materials. The total yield of this newly developed synthetic route for the target product was 43.15% with 99.7% of purity (HPLC). The structure of target molecular was confirmed by LC-MS and 1H NMR spectrum.
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