Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging

医学 齿状核 磁共振成像 核医学 苍白球 病理 放射科 中枢神经系统 内科学 基底神经节 化学 有机化学 小脑
作者
Robert J. McDonald,Jennifer S. McDonald,David F. Kallmes,Mark E. Jentoft,David Murray,Kent R. Thielen,Eric E. Williamson,Laurence J. Eckel
出处
期刊:Radiology [Radiological Society of North America]
卷期号:275 (3): 772-782 被引量:1099
标识
DOI:10.1148/radiol.15150025
摘要

To determine if repeated intravenous exposures to gadolinium-based contrast agents (GBCAs) are associated with neuronal tissue deposition.In this institutional review board-approved single-center study, signal intensities from T1-weighted magnetic resonance (MR) images and postmortem neuronal tissue samples from 13 patients who underwent at least four GBCA-enhanced brain MR examinations between 2000 and 2014 (contrast group) were compared with those from 10 patients who did not receive GBCA (control group). Antemortem consent was obtained from all study participants. Neuronal tissues from the dentate nuclei, pons, globus pallidus, and thalamus of these 23 deceased patients were harvested and analyzed with inductively coupled plasma mass spectrometry (ICP-MS), transmission electron microscopy, and light microscopy to quantify, localize, and assess the effects of gadolinium deposition. Associations between cumulative gadolinium dose, changes in T1-weighted MR signal intensity, and ICP-MS-derived tissue gadolinium concentrations were examined by using the Spearman rank correlation coefficient (ρ).Compared with neuronal tissues of control patients, all of which demonstrated undetectable levels of gadolinium, neuronal tissues of patients from the contrast group contained 0.1-58.8 μg gadolinium per gram of tissue, in a significant dose-dependent relationship that correlated with signal intensity changes on precontrast T1-weighted MR images (ρ = 0.49-0.93). All patients in the contrast group had relatively normal renal function at the time of MR examination. Gadolinium deposition in the capillary endothelium and neural interstitium was observed only in the contrast group.Intravenous GBCA exposure is associated with neuronal tissue deposition in the setting of relatively normal renal function. Additional studies are needed to investigate the clinical significance of these findings and the generalizability to other GBCAs. Online supplemental material is available for this article.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
外向的醉易完成签到,获得积分10
1秒前
SharonDu完成签到 ,获得积分10
2秒前
3秒前
yuncong323完成签到,获得积分10
4秒前
huohuo完成签到,获得积分10
6秒前
CB完成签到,获得积分10
7秒前
7秒前
8秒前
儒雅路人完成签到,获得积分10
9秒前
OLDBLOW完成签到,获得积分10
10秒前
10秒前
liupangzi完成签到,获得积分10
10秒前
wang完成签到,获得积分10
10秒前
11秒前
Catherkk发布了新的文献求助10
11秒前
lcdamoy完成签到,获得积分10
12秒前
钱浩然发布了新的文献求助10
12秒前
烊烊发布了新的文献求助10
13秒前
十曰完成签到,获得积分10
18秒前
jjjjchou完成签到,获得积分10
19秒前
虚心的不二完成签到 ,获得积分10
21秒前
xuzj应助科研通管家采纳,获得10
22秒前
小马甲应助科研通管家采纳,获得10
22秒前
22秒前
思源应助科研通管家采纳,获得10
22秒前
22秒前
研友_VZG7GZ应助科研通管家采纳,获得10
22秒前
fang应助科研通管家采纳,获得10
22秒前
隐形曼青应助科研通管家采纳,获得10
22秒前
科研通AI5应助科研通管家采纳,获得10
22秒前
FashionBoy应助科研通管家采纳,获得10
22秒前
shiizii应助科研通管家采纳,获得10
22秒前
24秒前
火星上的雨莲完成签到,获得积分10
28秒前
开朗的绮山发布了新的文献求助150
28秒前
平淡远山发布了新的文献求助10
29秒前
热心市民小红花应助Roman采纳,获得10
30秒前
艺术家完成签到 ,获得积分10
31秒前
研友_ngqjz8完成签到,获得积分10
32秒前
LT完成签到 ,获得积分0
33秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038235
求助须知:如何正确求助?哪些是违规求助? 3575992
关于积分的说明 11374009
捐赠科研通 3305760
什么是DOI,文献DOI怎么找? 1819276
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022