Effectiveness of 0.12% Chlorhexidine Gluconate Oral Rinse in Reducing Prevalence of Nosocomial Pneumonia in Patients Undergoing Heart Surgery

医学 肺炎 呼吸机相关性肺炎 葡萄糖酸洗必泰 洗必泰 随机对照试验 机械通风 内科学 外科 麻醉 牙科
作者
Susan M. Houston,Paul Hougland,John E. Anderson,Mark LaRocco,Virginia Kennedy,Layne O. Gentry
出处
期刊:American Journal of Critical Care [AACN Publishing]
卷期号:11 (6): 567-570 被引量:268
标识
DOI:10.4037/ajcc2002.11.6.567
摘要

Decreasing the levels of bacteria in the oropharynx should reduce the prevalence of nosocomial pneumonia.To test the effectiveness of 0.12% chlorhexidine gluconate oral rinse in decreasing microbial colonization of the respiratory tract and nosocomial pneumonia in patients undergoing open heart surgery.A prospective, randomized, case-controlled clinical trial design was used. Peridex (0.12% chlorhexidine gluconate) was the experimental drug, and Listerine (phenolic mixture) was the control drug. A total of 561 patients undergoing aortocoronary bypass or valve surgery requiring cardiopulmonary bypass were randomized to an experimental (n = 270) or a control (n = 291) group. Nosocomial pneumonia was diagnosed by using the criteria established by the Centers for Disease Control and Prevention.The overall rate of nosocomial pneumonia was reduced by 52% (4/270 vs 9/291; P = .21) in the Peridex-treated patients. Among patients intubated for more than 24 hours who had cultures that showed microbial growth (all pneumonias occurred in this group), the pneumonia rate was reduced by 58% (4/19 vs 9/18; P = .06) in patients treated with Peridex. In patients at highest risk for pneumonia (intubated > 24 hours, with cultures showing the most growth), the rate was 71% lower in the Peridex group than in the Listerine group (2/10 vs 7/10; P = .02).Although rates of nosocomial pneumonia were lower in patients treated with Peridex than in patients treated with Listerine, the difference was significant only in those patients intubated more than 24 hours who had the highest degree of bacterial colonization.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
n张黎明完成签到,获得积分10
刚刚
离开后的心碎完成签到 ,获得积分10
1秒前
梦在彼岸应助白华苍松采纳,获得20
1秒前
热情冰凡发布了新的文献求助10
1秒前
dongshanshan完成签到,获得积分20
2秒前
YJ发布了新的文献求助10
2秒前
美好斓应助海晨采纳,获得100
3秒前
qifeng完成签到,获得积分10
4秒前
5秒前
5秒前
5秒前
idance发布了新的文献求助10
5秒前
7秒前
8秒前
8秒前
wZx发布了新的文献求助10
9秒前
Lau完成签到,获得积分10
9秒前
wb发布了新的文献求助10
10秒前
安然发布了新的文献求助10
11秒前
11秒前
深情安青应助一苇莆采纳,获得10
11秒前
bvhj完成签到,获得积分10
11秒前
11秒前
春眠不觉小小酥完成签到,获得积分10
11秒前
11秒前
夏夏发布了新的文献求助10
12秒前
LIU完成签到,获得积分10
12秒前
大模型应助狗狗的灌汤包采纳,获得10
13秒前
idance完成签到,获得积分20
13秒前
大模型应助科研通管家采纳,获得10
13秒前
小蘑菇应助科研通管家采纳,获得10
13秒前
Owen应助科研通管家采纳,获得10
14秒前
桐桐应助科研通管家采纳,获得10
14秒前
领导范儿应助张张采纳,获得10
14秒前
完美世界应助科研通管家采纳,获得10
14秒前
Ava应助科研通管家采纳,获得10
14秒前
JamesPei应助科研通管家采纳,获得10
14秒前
14秒前
搜集达人应助科研通管家采纳,获得10
14秒前
ccm应助科研通管家采纳,获得10
14秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
An Introduction to Geographical and Urban Economics: A Spiky World Book by Charles van Marrewijk, Harry Garretsen, and Steven Brakman 600
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3154309
求助须知:如何正确求助?哪些是违规求助? 2805114
关于积分的说明 7863632
捐赠科研通 2463326
什么是DOI,文献DOI怎么找? 1311205
科研通“疑难数据库(出版商)”最低求助积分说明 629506
版权声明 601821