活性氧
胞浆
细胞内
阳离子聚合
膜
生物物理学
基因传递
材料科学
氧气
聚合物
阿霉素
载体(分子生物学)
生物
转染
基因
生物化学
高分子化学
化学
重组DNA
有机化学
遗传学
复合材料
酶
化疗
作者
Xin Liu,Jiajia Xiang,Dingcheng Zhu,Liming Jiang,Zhuxian Zhou,Jianbin Tang,Xiangrui Liu,Yongzhuo Huang,Youqing Shen
标识
DOI:10.1002/adma.201504288
摘要
A novel fusogenic lipidic polyplex (FLPP) vector is designed to fuse with cell membranes, mimicking viropexis, and eject the polyplex into the cytosol, where the cationic polymer is subsequently oxidized by intracellular reactive oxygen species and converts to being negatively charged, efficiently releasing the DNA. The vector delivering suicide gene achieves significantly better inhibition of tumor growth than doxorubicin.
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