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Acyclovir: Discovery, mechanism of action, and selectivity

病毒学 图书馆学 生物 引用 医学杂志 鸟嘌呤 医学 计算机科学 遗传学 基因 核苷酸
作者
Elion Gb
出处
期刊:Journal of Medical Virology [Wiley]
卷期号:41 (S1): 2-6 被引量:179
标识
DOI:10.1002/jmv.1890410503
摘要

Journal of Medical VirologyVolume 41, Issue S1 p. 2-6 Article Acyclovir: Discovery, mechanism of action, and selectivity Dr. G. B. Elion, Corresponding Author Dr. G. B. Elion Wellcome Research Laboratories, Research Triangle Park, North CarolinaScientist Emeritus, Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709===Search for more papers by this author Dr. G. B. Elion, Corresponding Author Dr. G. B. Elion Wellcome Research Laboratories, Research Triangle Park, North CarolinaScientist Emeritus, Wellcome Research Laboratories, 3030 Cornwallis Road, Research Triangle Park, NC 27709===Search for more papers by this author First published: 1993 https://doi.org/10.1002/jmv.1890410503Citations: 158AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Biron KK, Elion GB (1980): In vitro susceptibility of varicella-zoster virus to acyclovir. Antimicrobial Agents & Chemotherapy 18: 443–447. 10.1128/AAC.18.3.443 CASPubMedWeb of Science®Google Scholar Colby BM, Furman PA, Shaw JE, Elion GB, Pagano JS (1981): Phosphorylation of acyclovir [9-(2-hydroxyethoxymethyl)guanine] in Epstein-Barr virus-infected lymphoblastoid cell lines. Journal of Virology 38: 606–611. CASPubMedWeb of Science®Google Scholar Datta AK, Colby BM, Shaw JE, Pagano JS (1980): Acyclovir inhibition of Epstein-Barr virus replication. Proceedings of the National Academy of Sciences, USA 77: 5173–5176. 10.1073/pnas.77.9.5163 Web of Science®Google Scholar Elion GB (1982): Mechanisms of action and selecticity of acyclovir. American Journal of Medicine 73(1A): 7–13. 10.1016/0002-9343(82)90055-9 CASPubMedWeb of Science®Google Scholar Elion GB (1986): History, mechanism of action, spectrum and selectivity of nucleoside analogs. In J Mills, L Corey (eds): “ New Directions for Clinical Application and Research.” New York: Elsevier, pp 118–137. Google Scholar Elion GB, Furman PA, Fyfe JA, DeMiranda P, Beauchamp L, Schaeffer HJ (1977): Selectivity of action of an antiherpetic agent, 9(2-hydroxyethoxymethyl)guanine. Proceedings of the National Academy of Sciences USA 74: 5716–5720. 10.1073/pnas.74.12.5716 CASPubMedWeb of Science®Google Scholar Furman PA, St Clair MH, Fyfe JA, Rideout JL, Keller PM, Elion GB (1979): Inhibition of herpes simplex virus-induced DNA polymerase acticity and viral DNA replication by 9–(2—hydroxyethoxymethyl)-guanine and its triphosphate. Journal of Virology 32: 72–77. CASPubMedWeb of Science®Google Scholar Furman PA, Coen DM, St Clair MH, Schaffer PA (1981): Acyclovirresistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities. Journal of Virology 40: 936–941. CASPubMedWeb of Science®Google Scholar Furman PA, St Clair MH, Spector T (1984): Acyclovir triphosphate is a suicide inactivator of the herpes simplex virus DNA polymerase. Journal of Biological Chemistry 259: 9575–9579. CASPubMedWeb of Science®Google Scholar Fyfe JA, Keller PM, Furman PA, Miller RL, Elion GB (1978): Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound 9-(2-hydroxyethoxymethyl)guanine. Journal of Biological Chemistry 253: 8721–8727. CASPubMedWeb of Science®Google Scholar Keller PM, Fyfe JA, Beauchamp L, Lubbers CM, Furman PA, Schaeffer HJ, Elion GB (1981): Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities. Biochemical Pharmacology 30: 3071–3077. 10.1016/0006-2952(81)90495-0 CASPubMedWeb of Science®Google Scholar Keller PM, McKee SA, Fyfe JA (1985): Cytoplasmic 5′-nucleotidase catalyzes acyclovir phosphorylation. Journal of Biological Chemistry 260: 8664–8667. CASPubMedWeb of Science®Google Scholar Mahony WB, Domin BA, McConnell RT, Zimmerman T (1988): Acyclovir transport into human erythrocytes. Journal of Biological Chemistry 263: 9285–9291. CASPubMedWeb of Science®Google Scholar McGuirt PV, Furman PA (1982): Acyclovir inhibition of viral DNA chain elongation in herpes simplex virus-infected cells. American Journal of Medicine 73(1A): 67–71. 10.1016/0002-9343(82)90066-3 CASPubMedWeb of Science®Google Scholar Miller WH, Miller RL (1980): Phosphorylation of acyclovir (aycloguanoise) monophosphate by GMP kinase. Journal of Biological Chemistry 255: 7204–7207. CASPubMedWeb of Science®Google Scholar Miller WH, Miller RL (1982): Phosphrolation of acylovir diphospahte by celluar enzymes. Biochemical Pharmacology 31: 3879–3884. 10.1016/0006-2952(82)90305-7 CASPubMedWeb of Science®Google Scholar Reardon JE, Spector T (1989): Herpes simplex virus type 1 DNA polymerase: Mechanism of inhibition by acyclovir triphosphate. Journal of Biological Chemistry 264: 7405–7411. CASPubMedWeb of Science®Google Scholar Schaeffer HJ, Beauchamp L, DeMiranda P, Elion GB, Bauer DJ, Collins P (1978): 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group. Nature 272: 583–585. 10.1038/272583a0 CASPubMedWeb of Science®Google Scholar St Clair MH, Furman PA, Lubbers CM, Elion GB (1980): Inhibition of cellular α and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir. Antimicrobial Agents & Chemotherapy 18: 742–745. 10.1128/AAC.18.5.741 Google Scholar Citing Literature Volume41, IssueS1Supplement: Proceeding from an international symposium held in Berlin, Germany1993Pages 2-6 ReferencesRelatedInformation
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