细胞内
组胺
刺激
生物物理学
离子运输机
化学
内皮干细胞
电场
内分泌学
内科学
生物
生物化学
体外
医学
膜
物理
量子力学
作者
Kimiko Takahashi,Masahiko Kuroki,Fuyuki Doge,Yoshio Sawasaki,M. Yoshioka
标识
DOI:10.1081/jbc-120016002
摘要
Human vascular endothelial cells (HUVEC) were exposed to air electric fields of 30 kV/m, 50 Hz for 24 hr. After exposure, the change in intracellular Ca2+ concentration ([Ca2+]i) induced by the vasoactive substances ATP and histamine were determined using confocal laser scanning microscopy. A statistically significant increase in [Ca2+]i was observed following stimulation with 100 μM ATP, compared with the results in sham-exposed cells (22%, p<0.05, n=20). No changes in [Ca2+]i due to the field were observed after stimulation with histamine, showing that the effect of the field on the change in [Ca2+]i was agonist-specific. The Ca2+ concentration in the medium was low, suggesting that the ATP-induced increase in [Ca2+]i in cells exposed to electric fields was due to the release of Ca2+ from intracellular stores. The results suggested that the applied low-frequency electric field affected the function of HUVEC via a change in [Ca2+]i.
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