赫拉
细胞凋亡
阴沟肠杆菌
多糖
体外
化学
宫颈癌
癌细胞
微生物学
癌症
宫颈癌
细胞生物学
生物
生物化学
基因
肠杆菌科
大肠杆菌
遗传学
作者
Ke Zhao,Mingliang Jin,Qing Chen,Peng‐Sheng Zheng
标识
DOI:10.1016/j.ijbiomac.2014.09.047
摘要
The effects and possible mechanism of polysaccharides produced by Enterobacter cloacae (EPS) on cervical cancer cells (Hela and SiHa) were investigated in vitro in the current study. The results showed that supplementation of EPS inhibited the proliferation of HeLa and SiHa cells in a concentration- and time-dependent manner. In addition, the EPS also induced the apoptosis of the cervical cancer cells by changing the nuclear morphology and decreasing the mitochondrial membrane potential. Furthermore, the EPS-induced apoptosis was associated with the regulation of Bcl-2 family protein expression. In particular, the pro-apoptotic protein Bak-1 was increased and anti-apoptotic protein Bcl-2 was decreased with the increasing concentration at certain range of EPS. These results indicated that EPS might induce the apoptosis of cervical cancer cells through an intrinsic apoptotic pathway, and EPS may act as potent antitumor agents.
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