计算生物学
核糖核酸
鸟嘌呤
尿嘧啶
胞嘧啶
序列同源性
序列(生物学)
生物
核酸结构
RNA结合蛋白
DNA
生物化学
基序列
基因
核苷酸
作者
Aleksandra Filipovska,Muhammad Fazril Mohamad Razif,Karoline K.A. Nygård,Oliver Rackham
摘要
The design of proteins that can bind any RNA sequence of interest has many potential biological and medical applications. Here we have expanded the recognition of Pumilio and FBF homology protein (PUF) repeats beyond adenine, guanine and uracil and evolved them to specifically bind cytosine. These repeat sequences can be used to create PUF domains capable of selectively binding RNA targets of diverse sequence and structure.
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