碳酸酐酶
酶
化学
同工酶
活动站点
激活剂(遗传学)
基因亚型
胺气处理
生物化学
药品
分子
立体化学
生物
药理学
有机化学
受体
基因
作者
Claudia Temperini,Andrea Scozzafava,Claudiu T. Supuran
标识
DOI:10.2174/138161208783877857
摘要
The activation mechanism of Carbonic Anhydrase was recently explained using kinetic, spectroscopic and X-ray techniques. It has been demonstrated that the activators molecules (CAAs) bind at the entrance of the enzyme active-site facilitating the ratedetermining step of CA catalitic cycle. Drug design studies have been performed in order to obtain strong CAAs belonging to several chemical classes: amino acids, azoles, amine and their derivatives, etc. Structure-activity correlations of different activators are discussed for the most studied Carbonic Anhydrase isozymes: isoform I and II. The physiological relevance of CA activation and the possible application of CAAs in Alzheimers desease and for other memory therapies are also treated. Keywords: Carbonic anhydrase, X-ray structure, kinetic, enzyme activator, Alzheimer's desease
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