卵泡期
医学
体外受精
妊娠率
怀孕
人口
卵巢过度刺激综合征
促卵泡激素
男科
内分泌学
内科学
妇科
促黄体激素
激素
生物
环境卫生
遗传学
作者
Anders Nyboe-Andersen,Peter Humaidan,Gerald M. Fried,Jon Hausken,L Antila,Susanne Bangsbøll,PE Rasmussen,Svend Lindenberg,H.E. Bredkjær,Helle Meinertz
出处
期刊:Human Reproduction
[Oxford University Press]
日期:2007-11-17
卷期号:23 (2): 427-434
被引量:58
标识
DOI:10.1093/humrep/dem317
摘要
The purpose of this multicentre, multinational trial was to study whether rLH supplementation to recombinant FSH (rFSH) during the late follicular phase increased pregnancy rates.After down-regulation with nafarelin, 526 women were randomized on Day 1 of stimulation to use either rFSH (Gonal-F) alone (n = 261) or to continue after Day 6 of stimulation with both rFSH (Gonal-F) and rLH (Luveris) (n = 265) from Day 6. The starting dose of rFSH was 150-225 IU/day according to age below or above 35 years.Ongoing pregnancy rate at week 10-12 was 28.7% after rFSH alone and 27.2% after rFSH + rLH. This showed no evidence of a difference. Administration of rLH significantly (P< 0.001) increased serum LH. Ongoing pregnancy rates in patients with low LH levels (<33 percentile) on Days 1 and 6 of stimulation showed no difference between the group treated with rFSH only (23.9% low Day 1 LH; 22.1% low Day 6 LH) versus rFSH + rLH (25.0% low Day 1 LH; 28.9% low Day 6 LH).Supplementing rFSH with daily doses of 75-150 IU of rLH during the second half of the follicular phase showed no evidence of increasing the ongoing pregnancy rates in the general population. (ClinicalTrials.gov, trial number: KF02-035/03).
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