Differentiation, differentiation/gene therapy and cancer

“Differentiation, Differentiation/Gene Therapy and Cancer” is intended to suggest that an understanding of the cell and molecular biology of cell differentiation should advance the development of new cancer therapies. This article, therefore, reviews four general topics and their relationship to each other: (1) the multistep process of cell differentiation in nontransformed and transformed cells, (2) the use of drugs that induce differentiation in vitro as potential clinical differentiation therapy agents for cancer, (3) the evolving emphasis on gene therapy as a new cancer therapy modality, and (4) the concept of differentiation/ gene therapy.