分泌物
生物发生
效应器
毒力
ATP水解
ATP酶
细胞生物学
生物
三型分泌系统
生物化学
基因
酶
作者
Alejandro Peña,Ignacio Aréchaga
出处
期刊:Microbial physiology
日期:2013-01-01
卷期号:23 (4-5): 357-369
被引量:12
摘要
Secretion of effectors across bacterial membranes is usually mediated by large multisubunit complexes. In most cases, the secreted effectors are virulent factors normally associated to pathogenic diseases. The biogenesis of these secretion systems and the transport of the effectors are processes that require energy. This energy could be directly obtained by using the proton motive force, but in most cases the energy associated to these processes is derived from ATP hydrolysis. Here, a description of the machineries involved in generating the energy required for system biogenesis and substrate transport by type II, III and IV secretion systems is provided, with special emphasis on highlighting the structural similarities and evolutionary relationships among the secretion ATPases.
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