迷迭香酸
紫苏
紫苏
没食子酸
化学
乙酸乙酯
DPPH
抗氧化剂
色谱法
IC50型
萃取(化学)
食品科学
传统医学
生物化学
有机化学
体外
医学
原材料
作者
Fengxian Zhu,Takayuki Asada,Akihiko Sato,Yoriko Koi,Hisashi Nishiwaki,Hirotoshi Tamura
摘要
Rosmarinic acid extract with potent biological activities was successfully isolated by supramolecular technique and solvent extraction from Perilla leaves. By the supramolecular complex which was formed from flavocommelin and Perilla leaf extract as initial materials, the supernatant containing rosmarinic acid was isolated. Rosmarinic acid extract (62.9 ± 4.5% purity) was partly purified by partitioning ethyl acetate and water. Rosmarinic acid extract exhibited high total phenolic content of 433.9 ± 58.6 μg/mg of gallic acid equivalent, effective DPPH radical scavenging activity (SC50 of 5.5 ± 0.2 μg/mL), antiallergic activity (IC50 of 52.9 ± 6.7 μg/mL), and α-glucosidase inhibitory activity (IC50 of 0.23 ± 0.01 mg/mL). Rosmarinic acid extract shows high potential for diabetes mellitus and allergy treatments by inhibiting α-glucosidase activity and measuring β-hexosaminidase, related to life-style disease.
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