Parathyroid hormone-related protein induces hypertrophy in podocytes via TGF- 1 and p27Kip1: implications for diabetic nephropathy

PTHrP seems to participate in the hypertrophic signalling triggered by HG. In this condition, AngII induces the upregulation of PTHrP, which might induce the expression of TGF-beta(1) and p27(Kip1). These findings provide new insights into the protective effects of AngII antagonists in DN, opening new paths for intervention.