Increased Myogenic Tone and Diminished Responsiveness to ATP-Sensitive K + Channel Openers in Cerebral Arteries From Diabetic Rats

吡那地尔 内科学 脑动脉 超极化(物理学) 内分泌学 血管收缩 硝普钠 医学 收缩 克罗马卡林 格列本脲 糖尿病 循环系统 心脏病学 化学 一氧化氮 核磁共振波谱 有机化学
作者
Paul Zimmermann,Harm J. Knot,Andrá S. Stevenson,Mark T. Nelson
出处
期刊:Circulation Research [Lippincott Williams & Wilkins]
卷期号:81 (6): 996-1004 被引量:128
标识
DOI:10.1161/01.res.81.6.996
摘要

Abstract Diabetes mellitus has profound adverse effects on vascular and, in particular, endothelial function. Although pressure-induced constriction (“myogenic tone”) is a major contributor to the regulation of blood flow, little is known about the effects of diabetes on this response. Diabetes has been shown to diminish the dilation of cerebral arteries to synthetic ATP-sensitive K + (K ATP ) channel openers. In this study, we explored the effects of diabetes induced in rats by streptozotocin on cerebral artery (250 to 300 μm) myogenic tone and on vasodilations to the synthetic K ATP channel openers pinacidil and levcromakalim. Elevation of intravascular pressure caused a graded membrane potential depolarization and constriction, which was greater in arteries from diabetic rats compared with normal rats (at 60 mm Hg, 5 mV more depolarized and 22 μm more constricted). Pressurized arteries (at 60 mm Hg) from diabetic rats were 5- to 15-fold less sensitive to pinacidil and levcromakalim than were control arteries (EC 50 values for pinacidil and levcromakalim were 1.4 and 0.6 μmol/L, respectively, in diabetic animals and 0.3 and 0.04, respectively, in control animals; P <.05). Removal of the endothelium or addition of a NO synthase inhibitor, N G -nitro- l -arginine (LNNA), in control arteries decreased the sensitivity to K ATP channel openers and depolarized and constricted control arteries to levels similar to those observed in arteries from diabetic animals. Sodium nitroprusside caused a membrane potential hyperpolarization and enhanced the response to pinacidil in arteries from diabetic animals. Removal of the endothelium or LNNA had little effect on the apparent K ATP channel opener sensitivity, the membrane potential, and pressure-induced constrictions of arteries from diabetic animals. The results are consistent with the hypothesis that this type of diabetes leads to a decrease in tonic NO release from the endothelium, which in turn causes membrane potential depolarization and vasoconstriction, resulting in a diminished response to K ATP channel openers.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
pep完成签到 ,获得积分10
刚刚
mufcyang完成签到,获得积分10
4秒前
了晨完成签到 ,获得积分10
5秒前
yi完成签到 ,获得积分10
8秒前
wxnice完成签到,获得积分10
9秒前
量子星尘发布了新的文献求助10
11秒前
星辰大海应助大橙子采纳,获得10
20秒前
20秒前
七QI完成签到 ,获得积分10
21秒前
24秒前
褚香旋完成签到,获得积分10
24秒前
一只狗东西完成签到 ,获得积分10
26秒前
宇老师发布了新的文献求助10
27秒前
28秒前
qiqi发布了新的文献求助30
30秒前
大橙子发布了新的文献求助10
33秒前
wzhang完成签到,获得积分10
34秒前
ken131完成签到 ,获得积分10
37秒前
myl完成签到,获得积分10
38秒前
728完成签到,获得积分10
44秒前
xiaofeng5838完成签到,获得积分10
44秒前
ronnie完成签到,获得积分10
44秒前
47秒前
寒冷芷蕊完成签到,获得积分20
47秒前
47秒前
Jane完成签到,获得积分10
47秒前
一氧化二氢完成签到,获得积分10
53秒前
凡事发生必有利于我完成签到,获得积分10
54秒前
yihaiqin完成签到 ,获得积分10
58秒前
轩辕剑身完成签到,获得积分0
58秒前
coolkid完成签到 ,获得积分0
59秒前
你怎么那么美完成签到,获得积分10
59秒前
游艺完成签到 ,获得积分10
1分钟前
冬月完成签到 ,获得积分10
1分钟前
薛乎虚完成签到 ,获得积分10
1分钟前
1分钟前
大胖完成签到,获得积分10
1分钟前
野火197完成签到,获得积分10
1分钟前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022