抗菌肽
抗菌剂
肽
选择性
抗菌肽
计算生物学
化学
组合化学
灵活性(工程)
生物化学
生物物理学
生物
抗菌活性
细菌
遗传学
数学
统计
催化作用
有机化学
作者
Davor Juretić,Juraj Simunić
标识
DOI:10.1080/17460441.2019.1642322
摘要
Introduction: Low-molecular-weight antibiotics are gradually rendered ineffective by multidrug-resistant bacteria. Promising replacements are fast-acting antimicrobial peptides, either found as host defense peptides or designed, but their main weakness in applications is low selectivity for bacterial cells.Areas covered: This paper explores how much human design has improved the evolutionary design for linear alpha-class antimicrobial peptides with a selective antibacterial activity. Activity data against E. coli and S. aureus are collected from numerous publications reporting the hemolytic activity as well. Overall performance parameters are defined for easier ranking of best-performing peptides.Expert opinion: Connecting structure to the specific activity of antimicrobial peptides should include considerations of which peptide features channel adaptable conformational changes toward pore-inducing interactions with anionic membranes. Imperfect amphipathicity, enhanced flexibility, self-assembly potential, and an oblique, only partially helical structure, can improve structure-activity and structure-selectivity relationships. The number of optimal combinations of antimicrobial activity and low toxicity are immense when dedicated databases are constructed, the best descriptors extracted and followed through model building, simulations, and selectivity predictions, with everything tightly connected to feedback cycles of in vitro testing.
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