The ability of thromboelastography parameters to predict severe pre‐eclampsia when measured during early pregnancy

Abstract Objective To examine the predictive value of thromboelastography parameters during early pregnancy as potential markers of severe pre‐eclampsia during late pregnancy. Methods An observational retrospective case–control study was conducted among pregnant women who attended a single hospital in Shanghai, China, between July 1, 2016, and February 31, 2018. Data were obtained from medical records and a structured questionnaire completed by the participants. Thromboelastography parameters included time r ; time k ; α angle; maximum amplitude; clot lysis at 60 minutes; and coagulation index. Other risk factors for severe pre‐eclampsia were also assessed. Results The pre‐eclampsia and control groups comprised 46 and 138 women, respectively. Women with a coagulation index below zero at 13–20 weeks experienced an increased risk of severe pre‐eclampsia (odds ratio [ OR ] 31.72, 95% confidence interval [ CI ] 11.28–89.24; P <0.001). Other risk factors for severe pre‐eclampsia were family history of hypertension ( OR 3.79, 95% CI 1.21–11.48; P =0.017) and pre‐pregnancy body mass index ( OR 2.83, 95% CI 1.14–7.36; P =0.023). Conclusion Coagulation index determined by thromboelastography was an early marker for severe pre‐eclampsia.