化学
烷基化
脱羧
区域选择性
试剂
烷基
有机化学
功能群
小学(天文学)
香豆素
组合化学
催化作用
天文
物理
聚合物
作者
Can Jin,Zhiyang Yan,Bin Sun,Can Jin
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-03-27
卷期号:21 (7): 2064-2068
被引量:81
标识
DOI:10.1021/acs.orglett.9b00327
摘要
An efficient photocatalytic decarboxylative 3-position alkylation of coumarins by using alkyl N-hydroxyphthalimide esters as alkylation reagents has been developed. A variety of NHP esters derived from aliphatic carboxylic acids (primary, secondary, and tertiary) has been proved to be tolerated for this decarboxylation process, affording a broad scope of 3-alkylated coumarin derivatives in moderate to excellent yields. This protocol was highlighted by its mild conditions, readily available starting materials, operational simplicity, and wide functional group tolerance.
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