糖尿病
细胞外小泡
低血糖
细胞外
胞外囊泡
病态的
医学
胰岛素抵抗
生物信息学
生物
内分泌学
内科学
细胞生物学
小RNA
微泡
生物化学
基因
作者
Fan Zhou,Liang Huang,Shun-Lin Qu,Ru Kwa Chao,Yang Chen,Zhisheng Jiang
标识
DOI:10.1016/j.cca.2019.07.032
摘要
Diabetes and diabetic vascular complications are now the leading cause of death in the world. The effects of traditional medical treatment are usually limited and accompanied by many side effects, such as hypoglycemia, obesity, liver and kidney damage, and gastrointestinal adverse reactions. Thus, it is urgent to explore some new strategies for the treatment of patients with diabetes. Recently, extracellular vesicles have received increased attention because of their emerging roles of cell–to–cell communication under physiological and pathological conditions. In addition, because of their abundant existence in almost all body fluids, as well as their plentiful cargos of bioactive proteins and miRNAs they carry, extracellular vesicles have a strong potential for therapeutic and diagnostic applications in many metabolic diseases, such as obesity and insulin resistance. Here, with the aim of providing the basis for the development of new treatments for diabetes, we review current understanding of extracellular vesicles and the critical roles it has played in the onset and progression of diabetes and diabetic complications.
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