血液病理学
不确定意义的单克隆抗体病
免疫分型
病理
细胞减少
淋巴细胞增多症
生物
髓样
免疫学
骨髓
单克隆
医学
细胞遗传学
单克隆抗体
遗传学
流式细胞术
基因
抗体
染色体
作者
Valentina Nardi,Frank C. Kuo,Robert P. Hasserjian
出处
期刊:American Journal of Clinical Pathology
[Oxford University Press]
日期:2019-07-15
卷期号:152 (3): 347-358
被引量:5
摘要
Abstract Objectives The 2017 Workshop of the Society for Hematopathology/European Association for Hematopathology aimed to review premalignant clonal hematopoietic proliferations. Methods The workshop panel reviewed 27 cases of clonal proliferations of indeterminate significance or potential (18 myeloid, nine lymphoid) and rendered consensus diagnoses. Results Immunophenotyping and genetic studies on peripheral blood, bone marrow, and lymph node samples have led to the incidental detection of small clonal populations in asymptomatic individuals. These premalignant clonal myeloid and lymphoid proliferations include monoclonal gammopathy of uncertain significance, monoclonal B-cell lymphocytosis, in situ follicular neoplasia, in situ mantle cell neoplasia, clonal hematopoiesis of indeterminate potential, and clonal cytopenia of undetermined significance. Conclusions Current diagnostic criteria for the diagnoses of premalignant clonal hematopoietic proliferations are reviewed and discussed in the context of the cases presented at the workshop.
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