Efficient AcrH2 Catalyzed β‐Trifluoromethylation of Carbonyl Compounds by Atom Transfer Radical Addition Reactions

Summary of main observation and conclusion The use of organic catalysis AcrH 2 enables the direct β‐trifluoromethylation of carbonyl compounds by atom transfer radical addition reactions with broad substrate scopes under mild conditions. This operationally simple and robust protocol successfully converts a variety of β‐chloro carbonyl compounds into the corresponding α‐chloro‐β‐fluoroalkylcarbonyl products. A significant advantage of this method is that it does not require the use of a metal catalyst, thereby avoiding metal residue problems in drug synthesis.