Glycerol Micellar Catalysis: An Efficient Multicomponent‐Tandem Green Synthetic Approach to Biologically Important 2, 4‐Disubstituted Thiazole Derivatives

Abstract A convenient, eco‐friendly, one‐pot, multi‐component synthesis of new 2, 4‐disubstituted hydrazinyl ‐ thiazoles under mild reaction conditions has been disclosed. The use of micellar catalysis in glycerol is the key aspect of this methodology which possesses superiority compared to glycerol alone. The other significant aspect of our findings is the use of inexpensive reagents, recyclability, mild reaction conditions, bioorganic compound as solvent cum promoter, short reaction time, high yield, column chromatography free etc. The present work proposes the construction of a variety of biologically active 2, 4‐disubstituted thiazole derivatives using different carbonyl compounds, thiosemicarbazide and α‐bromocarbonyl compounds. Due to its operational simplicity, this green and unexplored protocol can be easily applied for designing novel biologically active compounds.