CCL5
黑色素瘤
医学
趋化因子受体
CCR10
CCL7型
趋化因子受体CCR5
CXCR3型
C-C趋化因子受体6型
CXCL10型
CXCR4型
CXCL2型
CCR2型
CX3CL1型
C-C趋化因子受体7型
趋化因子受体
癌症
免疫学
炎症
作者
Nicolas Jacquelot,Connie P.M. Duong,Gabrielle T. Belz,Laurence Zitvogel
标识
DOI:10.3389/fimmu.2018.02480
摘要
The tumor microenvironment is highly heterogeneous. It is composed of a diverse array of immune cells that are recruited continuously into lesions. They are guided into the tumor through interactions between chemokines and their receptors. A variety of chemokine receptors are expressed on the surface of both tumor and immune cells rendering them sensitive to multiple stimuli that can subsequently influence their migration and function. These features significantly impact tumor fate and are critical in melanoma control and progression. Indeed, particular chemokine receptors expressed on tumor and immune cells are strongly associated with patient prognosis. Thus, potential targeting of chemokine receptors is highly attractive as a means to quench or eliminate unconstrained tumor cell growth.
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