Norfloxacin

This chapter discusses the norfloxacin. Norfloxacin is a synthetic antibacterial fluoroquinolone discovered in the late nineteen-seventies. It is related to nalidixic acid but its potency has been increased by a fluorine atom and by a piperazine moeity. In-vitro, it is active against a broad spectrum of gram-positive and gram-negative aerobic bacteria. Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. Its trademarks are noroxin, baccidal, and chibroxin. Its molecular weight is 319.34. Norfloxacin is a white to light yellow crystalline, odorless powder with a bitter taste. Norfloxacin forms complexes with different divalent metal ions in the molar ratio Norfloxacin to metal ion of 2 to 1. Anhydrous norfloxacin picks up moisture rapidly under ambient conditions to form different hydrates.