Characterization of cellular senescence in aging skeletal muscle

衰老 表型 生物 骨骼肌 细胞生物学 细胞老化 肌萎缩 细胞衰老 基因 端粒 解剖 生物化学 DNA
作者
Xu Zhang,Leena Habiballa,Zaira Aversa,Yan Er Ng,Ayumi Sakamoto,Davis A. Englund,Vesselina Pearsall,Thomas A. White,Matthew M. Robinson,Donato A. Rivas,Surendra Dasari,Adam Hruby,Anthony B. Lagnado,Sarah K. Jachim,Antoneta Granic,Avan Aihie Sayer,Diana Jurk,Ian R. Lanza,Sundeep Khosla,Roger A. Fielding
出处
期刊:Nature Aging 卷期号:2 (7): 601-615 被引量:124
标识
DOI:10.1038/s43587-022-00250-8
摘要

Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite profound age-associated changes in skeletal muscle (SkM), whether its constituent cells are prone to senesce has not been methodically examined. Herein, using single-cell and bulk RNA sequencing and complementary imaging methods on SkM of young and old mice, we demonstrate that a subpopulation of old fibroadipogenic progenitors highly expresses p16Ink4a together with multiple senescence-related genes and concomitantly, exhibits DNA damage and chromatin reorganization. Through analysis of isolated myofibers, we also detail a senescence phenotype within a subset of old cells, governed instead by p21Cip1. Administration of a senotherapeutic intervention to old mice countered age-related molecular and morphological changes and improved SkM strength. Finally, we found that the senescence phenotype is conserved in SkM from older humans. Collectively, our data provide compelling evidence for cellular senescence as a hallmark and potentially tractable mediator of SkM aging. Senescent cells accumulate with age and contribute to the functional decline of many tissues; however, their role in skeletal muscle is not well understood. Here the authors comprehensively assess cellular senescence in skeletal muscle of young and old mice and detail senescence features in subpopulations of p16+ fibroadipogenic progenitors and p21+ myofibers.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
33应助戴好头盔搞科研采纳,获得10
刚刚
hyx9504发布了新的文献求助10
1秒前
兔子里的乌龟完成签到 ,获得积分10
1秒前
香蕉觅云应助锅锅采纳,获得10
1秒前
轻松的亦寒应助wdlc采纳,获得20
2秒前
2秒前
3秒前
4秒前
练习时长两年半应助lucky采纳,获得10
4秒前
yar应助Zrf采纳,获得10
4秒前
4秒前
我是老大应助小花花采纳,获得10
4秒前
苏瑾完成签到,获得积分10
5秒前
陆千万完成签到,获得积分10
6秒前
欣慰的乌冬面完成签到,获得积分10
6秒前
香蕉觅云应助mayberichard采纳,获得10
6秒前
吴未完成签到,获得积分10
7秒前
香蕉觅云应助老实的黑米采纳,获得30
7秒前
8秒前
酷波er应助刘仁轨采纳,获得10
9秒前
短腿小柯基完成签到 ,获得积分10
9秒前
wanci应助赵小米采纳,获得10
9秒前
10秒前
成功应助円桑采纳,获得10
10秒前
天天快乐应助酷酷巧蟹采纳,获得10
11秒前
11秒前
11秒前
11秒前
11秒前
晨曦完成签到,获得积分10
11秒前
11秒前
慕青应助鲤鱼安青采纳,获得10
11秒前
小二郎应助风趣的老太采纳,获得10
12秒前
英姑应助臧佳莹采纳,获得10
12秒前
lei029完成签到,获得积分10
13秒前
13秒前
14秒前
大方弘文发布了新的文献求助10
15秒前
15秒前
yy完成签到,获得积分10
15秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975165
求助须知:如何正确求助?哪些是违规求助? 3519595
关于积分的说明 11198781
捐赠科研通 3255912
什么是DOI,文献DOI怎么找? 1798001
邀请新用户注册赠送积分活动 877343
科研通“疑难数据库(出版商)”最低求助积分说明 806298