衣霉素
脂肪变性
内质网
未折叠蛋白反应
蒜素
脂肪生成
化学
甘油三酯
辣椒素
川芎嗪
药理学
内分泌学
内科学
生物化学
生物
脂质代谢
医学
胆固醇
大蒜素
病理
替代医学
受体
作者
Ye‐Rang Yun,Ji-Eun Lee
标识
DOI:10.1016/j.jff.2022.105186
摘要
Recently, food ingredients that suppress endoplasmic reticulum (ER) stress have been studied for their potential application in non-alcoholic fatty liver disease (NAFLD) treatment. Kimchi active components can suppress ER stress-related markers; therefore, we investigated the inhibitory effects of alliin, capsaicin, and gingerol on tunicamycin-induced hepatic steatosis in HepG2 cells and C57BL/6N mice by measuring ER stress-, lipogenesis-, and inflammation-related gene expression, and lipid accumulation. Alliin, capsaicin, and gingerol efficiently decreased triglyceride content and all gene expression in tunicamycin-induced cells without cytotoxicity. Alliin, capsaicin, and gingerol inhibited lipogenesis-related gene expression that increased following T0901317 treatment and decreased following AICAR treatment. Furthermore, alliin, capsaicin, and gingerol decreased serum lipid and hepatic lipid levels and all marker expression in tunicamycin-induced mice without hepatic toxicity. They also inhibited lipid accumulation in tunicamycin-induced mice. Collectively, kimchi active components prevented triglyceride accumulation and hepatic steatosis in ER stress-induced HepG2 cells and C57BL/6N mice.
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