化学
立体化学
萜烯
环化酶
生物合成
产黄青霉
双环分子
细胞色素P450
戒指(化学)
基因簇
基质(水族馆)
生物化学
酶
基因
有机化学
地质学
海洋学
作者
Bowen Qi,Na Li,Beibei Zhang,Zekun Zhang,Wenjing Wang,Xiao Liu,Juan Wang,Takayoshi Awakawa,Pengfei Tu,Ikuro Abe,Shepo Shi,Jun Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-03-28
卷期号:24 (13): 2526-2530
被引量:9
标识
DOI:10.1021/acs.orglett.2c00684
摘要
The biosynthetic gene cluster of atlantinone B (10) was discovered in Penicillium chrysogenum MT-40. A multifunctional cytochrome P450 (AtlD) encoded by the cluster is responsible for the formation of the unique lactone-bridged ring and the 16β-hydroxyl of atlantinone B, and a new terpene cyclase (AtlC) can unprecedentedly accept the demethylated substrate epoxyfarnesyl-DMOA (4a) to generate three bicyclic meroterpenoids (5a-5c). This study paves the way for combinatorial synthesis of structurally diverse meroterpenoids for drug discovery.
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