青蒿素
疟疾
癌症治疗
药理学
医学
恶性疟原虫
联合疗法
药品
癌症
免疫学
内科学
作者
Sijongesonke Peter,Siphesihle Jama,Sibusiso Alven,Blessing A. Aderibigbe
出处
期刊:Molecules
[MDPI AG]
日期:2021-12-11
卷期号:26 (24): 7521-7521
被引量:22
标识
DOI:10.3390/molecules26247521
摘要
Cancer and malaria are major health conditions around the world despite many strategies and therapeutics available for their treatment. The most used strategy for the treatment of these diseases is the administration of therapeutic drugs, which suffer from several shortcomings. Some of the pharmacological limitations associated with these drugs are multi-drug resistance, drug toxicity, poor biocompatibility and bioavailability, and poor water solubility. The currently ongoing preclinical studies have demonstrated that combination therapy is a potent approach that can overcome some of the aforementioned limitations. Artemisinin and its derivatives have been reported to exhibit potent efficacy as anticancer and antimalarial agents. This review reports hybrid compounds containing artemisinin scaffolds and their derivatives with promising therapeutic effects for the treatment of cancer and malaria.
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