Formulation and evaluation of polymeric transdermal patch of Meloxicam

Transdermal patches of Meloxicam were prepared to reduce the side effects by oral application. Meloxicam patches were prepared through solvent casting method via various synthetic polymers like ethyl cellulose, PVP, PVA, ethyl cellulose, eudragit RS100, eudragit RL100) in various ratio. The DMSO was used as a penetration enhancer. Prepared patches were evaluated their weight, moisture content, thickness, folding endurance quality, tensile strength, drug content and in-vitro release. The result found, patch was to be flexible, uniform thickness, low moisture absorption and good drug content (92 to 96%). The modified Franz diffusion cell was used for In vitro studies, which showed 70–80% drug release at 40 hrs, followed Higuchi diffusion mechanism.