肌生成抑制素
肌发生
调节器
转化生长因子
骨骼肌
生物信息学
生物
心肌细胞
细胞生物学
计算生物学
遗传学
基因
内分泌学
作者
Mohammad Hassan Baig,Khurshid Ahmad,Jun Sung Moon,So‐Young Park,Jeong Ho Lim,Hee Jin Chun,Afsha Fatima Qadri,Ye Chan Hwang,Arif Tasleem Jan,Syed Sayeed Ahmad,Shahid Ali,Sibhghatulla Shaikh,Eun Ju Lee,Inho Choi
标识
DOI:10.3389/fphys.2022.876078
摘要
Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an important therapeutic target. Several strategies based on the use of natural compounds to inhibitory peptides are being used to inhibit the activity of MSTN. This review delivers an overview of the current state of knowledge about SM and myogenesis with particular emphasis on the structural characteristics and regulatory functions of MSTN during myogenesis and its involvements in various muscle related disorders. In addition, we review the diverse approaches used to inhibit the activity of MSTN, especially in silico approaches to the screening of natural compounds and the design of novel short peptides derived from proteins that typically interact with MSTN.
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