化学
钯
区域选择性
催化作用
溴化物
药物化学
功能群
磷化氢
配体(生物化学)
分子间力
立体化学
组合化学
有机化学
分子
生物化学
受体
聚合物
作者
Yanzhen Chen,Jian‐Guo Fu,Xiaoming Ji,Shu‐Sheng Zhang,Chen‐Guo Feng
摘要
A palladium-catalyzed intermolecular cross-coupling of unreactive C(sp3)-H bonds and azole C(sp2)-H bonds with bromide as a traceless directing group is described. The judicious selection of the bulky and electron-rich phosphine ligand is the key for the success of this cascade process. The protocol features a broad substrate scope, excellent regioselectivity, and good functional group tolerance.
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